Departament de Física

Blas Echebarria Dominguez

Associate professor
Campus Sud (UPC), Edifici P, Despatx 119
Doctor Marañon, 44-50
08028 Barcelona

Telèfon: +34 934016264
E-Mail: blas.echebarriaupc.edu
Web del grup de recerca: http://biocomsc.upc.edu/en
Web personal: http://futur.upc.edu/BlasEchebarriaDominguez

Short CV

2008-present: Associate Professor. Department of Physics, Universitat Politècnica de Catalunya.
2003-2008: Ramón y Cajal Research Fellow, Department of Applied Physics, Universitat Politècnica de Catalunya.
2002-2003: Chercheur Associé. CNRS. Laboratoire de Fisique Statistique. Ecole Normale Superieure de Paris. Paris, France.
2000-2002: Research Associate. Physics Department. Northeastern University. Boston, USA.
1998-2000: Postdoctoral fellow. Department of Applied Mathematics and Engineering Sciences. Northwestern University. Evanston, IL, USA.
1994-1998: PhD in Physics. Department of Physics and Applied Mathematics. University of Navarre. Pamplona, Spain.
1989-1994: BsC in Physics. University of the Basque Country


1- Biophysical modeling of cardiac cells: From ion channels to tissue
Alonso, S.; Alvarez-Lacalle, E.; Bragard, J.; Echebarria, B.
Biophysica 5, 1, article 5 (2025)

2- A mixture of mobility and meteorological data provides a high correlation with COVID-19 growth in an infection-naive population: a study for Spanish provinces
Conesa, D.; Lopez de Rioja, V.; Gullón, T.; Tauste Campo, A.; Prats, C.; Alvarez-Lacalle, E.; Echebarria, B.
Frontiers in public health 12, 1288531 (2024)

3- Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
Tarifa, C.; Vallmitjana, A.; Jiménez-Sábado, V.; Marchena, M.; Llach, A.; Herraiz, A.; Nolla-Colomer, C.; Ginel, A.; Montiel, J.; Ciruela, F.; Echebarria, B.; Benitez, R.; Cinca, J.; Hove-Madsen, L.
JACC: Basic to Translational Science 8, 1 (2023)

4- Black and gray box learning of amplitude equations: application to phase field systems
Kemeth, F.; Alonso, S.; Echebarria, B.; Moldenhawer, T.; Beta, C.; Kevrekidis, I.
Physical review. E 107, 025305-1-025305-8 (2023)

5- Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: overview and perspectives
Colman, M.; Alvarez-Lacalle, E.; Echebarria, B.; Sato, D.; Sutanto, H.; Heijman, J.
Frontiers in physiology 13, 836622:1-836622:30 (2022)

6- Conductance heterogeneities induced by multistability in the dynamics of coupled cardiac gap junctions
Bragard, J.; Witt, A.; Laroze, D.; Hawks, C.; Elorza, J.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.
Chaos 31, 073144-1-17 (2021)

7- Ca2+-CaM dependent inactivation of RyR2 underlies Ca2+ alternans in intact heart
Guo, W.; Benitez, R.; Hove-Madsen, L.; Alvarez-Lacalle, E.; Echebarria, B.
Circulation research 128, e63-e83 (2021)

8- Influence of the tubular network on the characteristics of calcium transients in cardiac myocytes
Marchena, M.; Echebarria, B.
PloS one 15, 0231056-1-0231056-20 (2020)

9- Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells
Marchena, M.; Echebarria, B.; Shiferaw, Y.; Alvarez-Lacalle, E.
PLoS computational biology 16, 9 (2020)

10- Modelización computacional cardiaca
Bragard, J.; Camara Rey, Oscar; Echebarria, B.; Pueyo, E.; Soudah, E.; Vazquez, M.
Revista española de cardiología 74, 65-71 (2020)

11- Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes
Conesa, D.; Echebarria, B.; Peñaranda, A.; Rodriguez Cantalapiedra, I.; Shiferaw, Y.; Alvarez-Lacalle, E.
PLoS computational biology 16, 6 (2020)

12- Gap junction dynamics induces localized conductance bistability in cardiac tissue
Hawks, C.; Elorza, J.; Witt, A.; Laroze, D.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.; Bragard, J.
International journal of bifurcation and chaos 29, 1930021:1-1930021:14 (2019)

13- Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale
Marchena, M.; Echebarria, B.
Frontiers in physiology 9, 1-14 (2018)

14- Minimal model for calcium alternans due to SR release refractoriness
Rodriguez Cantalapiedra, I.; Alvarez-Lacalle, E.; Peñaranda, A.; Echebarria, B.
Chaos 27, 093928-1-093928-13 (2017)

15- Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics
Alvarez-Lacalle, E.; Peñaranda, A.; Rodriguez Cantalapiedra, I.; Shiferaw, Y.; Echebarria, B.
Computing in Cardiology 42, 329-332 (2016)

16- Nonlinear physics of electrical wave propagation in the heart: a review
Alonso, S.; Baer, M.; Echebarria, B.
Reports on progress in physics 79, 096601-096700 (2016)

17- Influence of gap junction dynamics on the stability of reentrant waves in cardiac tissue
Hawks, C.; Elorza, J.; Echebarria, B.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Bragard, J.
Computing in Cardiology 42, 437-440 (2016)

18- Calcium Alternans is Due to an Order-Disorder Phase Transition in Cardiac Cells
Alvarez-Lacalle, E.; Echebarria, B.; Spalding, J.; Shiferaw, Y.
Physical review letters 114, 10 (2015)

19- Cardiac contraction induces discordant alternans and localized block
Radszuweit, M.; Alvarez-Lacalle, E.; Bär, M.; Echebarria, B.
Physical review E: statistical, nonlinear, and soft matter physics 91, 2 (2015)

20- Propagation malfunctions due to gap junction dysregulation
Rodriguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.
Computing in Cardiology 41, 1045-1048 (2015)

21- Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model
Lugo, C.A.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Hove-Madsen, L.; Echebarria, B.
American journal of physiology. Heart and circulatory physiology 306, H1540-H1552 (2014)

22- Modeling calcium dynamics in human atria
Rodriguez Cantalapiedra, I.; Lugo, C.A.; Peñaranda, A.; Hove-Madsen, L.; Echebarria, B.
Computing in Cardiology 40, 1071-1074 (2014)

23- Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans
Alvarez-Lacalle, E.; Peñaranda, A.; Rodriguez Cantalapiedra, I.; Hove-Madsen, L.; Echebarria, B.
Computing in Cardiology 40, 683-686 (2013)

24- Dependency of calcium alternans on ryanodine receptor refractoriness
Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Cinca, J.; Hove-Madsen, L.; Echebarria, B.
PloS one 8, 2 (2013)

25- Nonlinearities due to refractoriness in SR Ca release
Peñaranda, A.; Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.; Echebarria, B.
Computing in Cardiology 39, 297-300 (2013)

26- Cardiac dynamics: a simplified model for action potential propagation
Peñaranda, A.; Rodriguez Cantalapiedra, I.; Bragard, J.; Echebarria, B.
Theoretical biology and medical modeling 9, 50-68 (2012)

27- Effect of Ryanodine Receptor Refractoriness on the Induction of Calcium Alternans
Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Hove-Madsen, L.; Echebarria, B.
Biophysical journal 102(3), 308a-308a (2012)

28- Supernormal conduction in cardiac tissue promotes concordant alternans and action potential bunching
Echebarria, B.; Roeder, G.; Engel, H.; Davidsen, J.; Baer, M.
Physical review E: statistical, nonlinear, and soft matter physics 83, 4 (2011)

29- Calcium alternans produced by increased sarcoplasmic reticulum refractoriness
Rodriguez Cantalapiedra, I.; Lugo, C.A.; Peñaranda, A.; Echebarria, B.
Computers in Cardiology 38, 645-648 (2011)

30- Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue
Peñaranda, A.; Rodriguez Cantalapiedra, I.; Echebarria, B.
Computers in Cardiology 37, 661-664 (2010)

31- Phase-2 reentry in cardiac tissue: role of the slow calcium pulse
Rodriguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.; Bragard, J.
Physical review E: statistical, nonlinear, and soft matter physics 82, 011907-1-011907-13 (2010)

32- Onset of sidebranching in directional solidification
Echebarria, B.; Karma, A.; Gurevich, S.
Physical review E: statistical, nonlinear, and soft matter physics 81, 021608-1-021608-17 (2010)

33- Reexcitation mechanisms in epicardial tissue: role of Ito density heterogeneities and INa inactivation kinetics
Rodriguez Cantalapiedra, I.; Peñaranda, A.; Mont, L.; Brugada, J.; Echebarria, B.
Journal of theoretical biology 259, 850-859 (2009)

34- Growth kinetics of nanometric dendrites in metal-carbon thin films
Corbella, C.; Echebarria, B.; Ramirez de La Piscina, L.; Pascual, E.; Bertran, E.; Gonzalez Andujar, Jose Luis
Acta materialia 57, 4948-4956 (2009)

35- Characterization of the nonlinear content of the heart rate dynamics during myocardial ischemia
Benitez, R.; Alvarez-Lacalle, E.; Echebarria, B.; Gomis, P.; Vallverdu, M.; Caminal, P.
Medical engineering and physics 31, 660-667 (2009)

36- Global coupling in excitable media provides a simplified description of mechanoelectrical feedback in cardiac tissue
Alvarez-Lacalle, E.; Echebarria, B.
Physical review E: statistical, nonlinear, and soft matter physics 79, 31921-31930 (2009)

37- "Modelització matemàtica de la dinàmica cardíaca"
Echebarria, B.
Omnis cellula 18, 16-21 (2008)

38- Oscillatory Regime in Excitatory Media with Global Coupling: Application to Cardiac Dynamics
Alvarez-Lacalle, E.; Rodriguez, J.; Echebarria, B.
Computers in cardiology 35, 189-192 (2008)

39- Amplitude equation approach to spatiotemporal dynamics of cardiac alternans
Echebarria, B.; Karma, A.
Physical review E: statistical, nonlinear, and soft matter physics 76, 5-051911 (2007)

40- "Mechanisms for initiation of cardiac discordant alternans"
Echebarria, B.; Karma, A.
European physical journal. Special topics 146, 217-231 (2007)

41- Nonequilibrium ribbon model of twisted scroll waves
Echebarria, B.; Hakim, V.; Henry, H.
Physical review letters 96, 098301 (2006)

42- Spontaneous formation of nanometric multilayers of metal-carbon films by up-hill diffusion during growth
Corbella, C.; Echebarria, B.; Ramirez de La Piscina, L.; Pascual, E.; Gonzalez Andujar, Jose Luis; Bertran, E.
Applied physics letters 87, 213117-1-213117-3 (2005)

43- Necessity of investigating microstructure formation during directional solidification of transparent alloys in 3D
Bergeon, N.; Trivedi, R.; Billia, B.; Echebarria, B.; Karma, A.; Liu, S.; Weiss, C.; Mangelinck, N.
Advances in space research 36, 80-85 (2005)

44- Quantitative Phase-Field Model of Alloy Solidification
Echebarria, B.; Roger Folch, José; Alain, K.; Mathis, P.
Physical review E, statistical physics, plasmas, fluids, and related interdisciplinary topics 70, 1604-1-22 (2004)

45- Hydrothermal waves and corotating rolls in laterally heated convection in simple liquids
Perez-Garcia, C.; Madruga, S.; Echebarria, B.; Lebon, G.; Burguete, J.
Journal of non-equilibrium thermdynamics 29, 377-388 (2004)

46- Spatiotemporal control of cardiac alternans
Echebarria, B.; Karma, A.
Chaos 12, 923-930 (2002)

47- Instability and spatiotemporal dynamics of alternans in paced cardiac tissue
Echebarria, B.; Karma, A.
Physical review letters 88, 208101-1-208101-4 (2002)

48- Sideband instabilities and defects of quasipatterns
Echebarria, B.; Riecke, H.
Physica. D, Nonlinear phenomena 158, 45-68 (2001)

49- "Stability of hexagonal patterns in Bénard-Marangoni convection"
Echebarria, B.; Perez-Garcia, C.
Physical review E: statistical, nonlinear, and soft matter physics 63, 066307-1-066307-13 (2001)

50- "Instabilities of hexagonal patterns with broken chiral symmetry"
Echebarria, B.; Riecke, H.
Physica. D, Nonlinear phenomena 139, 97-108 (2000)

51- "Defect chaos of oscillating hexagons in rotating convection"
Echebarria, B.; Riecke, H.
Physical review letters 84, 4838-4841 (2000)

52- Stability of oscillating hexagons in rotating convection
Echebarria, B.; Riecke, H.
Physica. D, Nonlinear phenomena 143, 187-204 (2000)

53- "Thermal properties in surface-tension-driven convection"
Pérez-García, C.; Echebarria, B.; Bestehorn, M.
Physical review E: statistical, nonlinear, and soft matter physics 57, 475-481 (1998)

54- "Phase instabilities in hexagonal patterns"
Echebarria, B.; Perez-Garcia, C.
Europhysics letters 43, 35-40 (1998)

55- "Resonant interactions in Bénard-Marangoni convection in cylindrical containers"
Echebarria, B.; Krmpotic, D.; Perez-Garcia, C.
Physica. D, Nonlinear phenomena 99, 487-502 (1997)

56- "Bénard-Marangoni convection in small aspect ratio containers"
Maza, D.; Echebarria, B.; Perez-Garcia, C.; Mancini, H.
Physica scripta T67, 82-85 (1996)