Departament de Física

David Oriola Santandreu

Lecturer
Campus Sud (UPC), Edifici A
Avda. Diagonal, 649
08028 Barcelona

Telèfon: +34 934016379
E-Mail: david.oriolaupc.edu
Web del grup de recerca: https://biocomsc.upc.edu/en
Web personal: https://davidoriola.mystrikingly.com

From cells to organisms, living systems are inherently multiscale. To understand the biophysical principles of living systems across scales, my group uses concepts from soft matter,  nonlinear and out-of-equilibrium physics in close collaboration with experimentalists. In particular, we are interested in how mesoscopic physical properties in cells and tissues arise from the interaction of its constituent elements. We are also interested in developing analytical and computational methods to infer the mechanical properties of tissues from time-lapse imaging data. 


Short CV


2022 - present: Assistant Professor (Lecturer), Department of Physics, Universitat Politècnica de Catalunya, Barcelona.
2019 - 2022: Postdoctoral Researcher, Juan de la Cierva Incorporación Fellow, European Molecular Biology Laboratory, EMBL Barcelona, Barcelona.
2016 - 2019: Postdoctoral Researcher, EMBO Long Term Postdoctoral Fellow, Max Planck Institute for the Physics of Complex Systems & Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.
2011 - 2016: Ph.D. in Physics, FPU Fellow, Universitat de Barcelona. Short Stays in the AMOLF Institute and the Wolfson Center for Mathematical Biology.
2006 - 2010: B.Sc. in Physics, University of Barcelona.


1- Early autonomous patterning of the anteroposterior axis in gastruloids
Anlas, K.; Gritti, N.; Nakaki, F.; Salamó, L.; Tlili, S.; Oriola, D.; Arató, K.; Lim, J.; Sharpe, J.; Trivedi, V.
Development 151, 22, dev202171 (2024)

2- Arrested coalescence: a tool to explore tissue rheology
Samatas, S.; Planasdemunt-Hospital, M.; Oriola, D.
Biophysica 4, 604-618 (2024)

3- Single-cell Bayesian deconvolution
Torregrosa, G.; Oriola, D.; Trivedi, V.; García, J.
iScience 26, 107941 (2023)

4- Arrested coalescence of multicellular aggregates
Oriola, D.; Marin, M.; Anlas, K.; Gritti, N.; Sanaki-Matsumiya, M.; Aalderink, G.; Ebisuya, M.; Sharpe, J.; Trivedi, V.
Soft matter 18, 3771-3780 (2022)

5- A gelation transition enables the self-organization of bipolar metaphase spindles
Oriola, D.; Dalton, B.; Decker, F.; Jülicher, F.; Brugués, J.
Nature physics 18, 323-331 (2022)

6- Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration
Riquelme, C.; Tsai, S.; Carreon, K.; Nguyen, C.; Oriola, D.; Schuez, M.; Brugués, J.; Currie, J.; Sandoval, T.
eLife 11, e79966 (2022)

7- Rethinking embryology in vitro: A synergy between engineering, data science and theory
Gritti, N.; Oriola, D.; Trivedi, V.
Developmental biology 474, 48-61 (2021)

8- Engineering life in synthetic systems
Oriola, D.; Spagnoli, F.
Development 148, dev199497 (2021)

9- Active forces shape the metaphase spindle through a mechanical instability
Oriola, D.; Jülicher, F.; Brugués, J.
Proceedings of the National Academy of Sciences of the United States of America 117, 16154-16159 (2020)

10- A Brownian Ratchet Model Explains the Biased Sidestepping of Single-Headed Kinesin-3 KIF1A
Mitra, A.; Suñé, M.; Diez, S.; Sancho, J.; Oriola, D.; Casademunt, J.
Biophysical journal 116, 2266-2274 (2019)

11- The physics of the metaphase spindle
Oriola, D.; Needleman, D.; Brugués, J.
Annual Review of Biophysics 47, 655-673 (2018)

12- Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles
Decker, F.; Oriola, D.; Dalton, B.; Brugués, J.
eLife 7, e31149 (2018)

13- Nonlinear amplitude dynamics in flagellar beating
Oriola, D.; Bloomfield-Gadêlha, H.; Casademunt, J.
Royal Society open science 4, 160698 (2017)

14- Fluidization and Active Thinning by Molecular Kinetics in Active Gels
Oriola, D.; Alert, R.; Casademunt, J.
Physical review letters 118, 088002 (2017)

15- Formation of helical membrane tubes around microtubules by single-headed kinesin KIF1A
Oriola, D.; Roth, S.; Dogterom, M.; Casademunt, J.
Nature communications 6, 8025 (2015)

16- Subharmonic oscillations of collective molecular motors
Oriola, D.; Blanch-Mercader, C.; Bloomfield-Gadêlha, H.; Casademunt, J.
Europhysics letters 107, 18002 (2014)

17- Cooperative action of KIF1A Brownian motors with finite dwell time
Oriola, D.; Casademunt, J.
Physical review E: statistical, nonlinear, and soft matter physics 89, 032722 (2014)

18- Cooperative Force Generation of KIF1A Brownian Motors
Oriola, D.; Casademunt, J.
Physical review letters 111, 048103 (2013)