Departament de Física

Roberto Macovez

Associate professor
Campus Besós (UPC), Edifici DBA, Despatx C-2.8
Avda. Eduard Maristany, s/n
08019 Barcelona

Telèfon: +34 934016568
E-Mail: roberto.macovezupc.edu
Web del grup de recerca: https://gcm.upc.edu/en
Web personal: https://futur.upc.edu/RobertoMacovez

I carry out experimental research in molecular and macromolecular soft matter, employing techniques such as calorimetry, X-ray diffraction, and especially broadband dielectric spectroscopy. I work on molecular and polymeric glass formers, orientationally disordered crystals and plastic crystals, and binary mixtures and amorphous dispersions. The focus is on solid-solid phase transitions and glass transitions, and in particular on the conformational dynamics and relaxation dynamics associated with the glass transition (structural and Johari-Goldstein relaxations) in glasses and orientationally disordered solids.
My activity in recent years has focused on amorphous formulation of active pharmaceutical ingredients to enhance their bioavailability. I am currently in charge of the UPC semester of the European Master Biopham, which aims at creating a generation of experts in material science applied to the pharmaceutical industry.


Short CV


2020 - present: UPC person in charge of the Erasmus Mundus Joint Master Degree “Biopham”, run by a consortium of 4 European universities and financed by the EU (www.master-biopham.eu/).
2019 - present: Associate Professor at the Department of Physics, Universitat Politècnica de Catalunya.
2010 - 2019: Lecturer (Professor Lector), Department of Applied Physics and Nuclear Engineering (after 2015, Department of Physics), Universitat Politècnica de Catalunya.
2009 - 2010: Juan de la Cierva research associate (funded by the Spanish Ministerio de Ciencia e Innovación). Project: Optical nonlinearities in photonic structures, the Institute of Photonic Science (ICFO), Castelldefels.
2008: Postdoctoral research contract. The Institute of Photonic Science (ICFO), Castelldefels.
2004 - 2007: PhD in Natural Sciences. PhD thesis title: Surface electronic structure of fullerides: effects of correlation, electron-phonon coupling, and polymerization. Department of Physics, Zernike Institute for Advanced Materials, University of Groningen (The Netherlands).
1997 - 2003: Degree in Physics. University of Trieste (Italy).


1- Alginate-graft-polyacrylic acid electro-responsive hydrogels: Impact of the conducting polymer and application as hydrogen peroxide sensor
Ramirez, M.; Álvarez, A.; Resina, L.; Romanini, M.; Macovez, R.; Perez, M.; Aleman, C.
European polymer journal 219, article 113388 (2024)

2- Eutectic binary phase diagram and kinetically stable homogeneous co-amorphous mixtures of two imidazole drugs
Noor, W.; Macovez, R.; Zamora, P.; Tamarit, J. Ll.; Romanini, M.
Journal of molecular liquids 416, part B, article 126518 (2024)

3- pH and electrically responsive hydrogels with adhesive property
Ramirez, M.; Molins, M.; Garcia-Torres, J.; Romanini, M.; Macovez, R.; Perez, M.; Aleman, C.
Reactive and functional polymers 196, 105841 (2024)

4- Amorphous solid dispersions of curcumin in a poly(ester amide): antiplasticizing effect on the glass transition and macromolecular relaxation dynamics, and controlled release
Valenti, S.; Matteo Arioli; Jamett, A.; Tamarit, J. Ll.; Puiggalí, J.; Macovez, R.
International journal of pharmaceutics 644, 123333 (2023)

5- Dielectric spectroscopy studies of conformational relaxation dynamics in molecular glass-forming liquids
Romanini, M.; Macovez, R.; Valenti, S.; Noor, W.; Tamarit, J. Ll.
International journal of molecular sciences 24, 17189 (2023)

6- Eutectic mixture formation and relaxation dynamics of coamorphous mixtures of two benzodiazepine drugs
Valenti, S.; Cazorla, C.; Romanini, M.; Tamarit, J. Ll.; Macovez, R.
Pharmaceutics (Basel) 15, 196 (2023)

7- Drug-biopolymer dispersions: morphology-and temperature-dependent (anti)plasticizer effect of the drug and component-specific Johari–Goldstein relaxations
Valenti, S.; del Valle, LJ.; Romanini, M.; Mitjana, M.; Puiggali, J.; Tamarit, J. Ll.; Macovez, R.
International journal of molecular sciences 23, 2456 (2022)

8- Glass transition, crystallization kinetics, and inter-conformer relaxation dynamics of amorphous mitotane and related compounds
Romanini, M.; Pérez, A.; Macovez, R.
International journal of pharmaceutics 629, 122390 (2022)

9- Inter-enantiomer conversion dynamics and Johari–Goldstein relaxation of benzophenones
Romanini, M.; Macovez, R.; Tamarit, J. Ll.
Scientific reports 11, 20248 (2021)

10- Chloramphenicol loaded polylactide melt electrospun scaffolds for biomedical applications
Valenti, S.; del Valle, LJ.; Yousefzade, O.; Macovez, R.; Franco, L.; Puiggali, J.
International journal of pharmaceutics 606, 120897:1-120897:13 (2021)

11- Uniaxial negative thermal expansion in polymorphic 2-bromobenzophenone, due to aromatic interactions?
Romanini, M.; Rietveld, I.; Del Barrio, M.; Negrier, P.; Mondieig, D.; Macovez, R.; Céolin, R.; Tamarit, J. Ll.
Crystal growth & design 21, 2167-2175 (2021)

12- Comparative physical study of three pharmaceutically active benzodiazepine derivatives: crystalline versus amorphous state and crystallization tendency
Valenti, S.; Del Barrio, M.; Negrier, P.; Romanini, M.; Macovez, R.; Tamarit, J. Ll.
Molecular Pharmaceutics 18, 1819-1832 (2021)

13- Phase-selective conductivity enhancement and cooperativity length in PLLA/TPU nanocomposite blends with carboxylated carbon nanotubes
Valenti, S.; Yousefzade, O.; Puiggali, J.; Macovez, R.
Polymer 191, 122279-1-122279-10 (2020)

14- A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
Zygouri, P.; Spyrou, K.; Mitsari, E.; Del Barrio, M.; Macovez, R.; Patila, M.; Stamatis, H.; Verginadis, I. I.; Velalopoulou, A. P.; Evangelou, A. M.; Sideratou, Z.; Gournis, D.; Rudolf, P.
Scientific reports 10, 8244:1-8244:13 (2020)

15- On the microscopic origin of the cryoprotective effect in lysine solutions
Henao, A.; Ruiz, G.; Steinke, N.; Cerveny Murcia, Silvina; Macovez, R.; Busch, S.; McLain, S.; Lorenz, C.; Pardo, L.
Physical chemistry chemical physics : PCCP 22, 6919-6927 (2020)

16- Tuning molecular dynamics by hydration and confinement: Antiplasticizing effect of water in hydrated prilocaine nanoclusters
Ruiz, G.; Combarro, I.; McLain, S.; Schwartz, G.; Pardo, L.; Cerveny Murcia, Silvina; Macovez, R.
Physical chemistry chemical physics 21, 15576-15583 (2019)

17- Mixtures of m-fluoroaniline with apolar aromatic molecules: Phase behaviour, suppression of H-bonded clusters, and local H-bond relaxation dynamics
Romanini, M.; Del Barrio, M.; Macovez, R.; Capaccioli, S.; Tamarit, J. Ll.
Journal of molecular liquids 296, 111998:1-111998:8 (2019)

18- Polymorphism with conformational isomerism and incomplete crystallization in solid ethanolamine
Romanini, M.; Negrier, P.; Tripathi, P.; Gournis, D.; Lira, K.; Del Barrio, M.; Pardo, L.; Tamarit, J. Ll.; Macovez, R.
Crystal growth and design 19, 6360-6369 (2019)

19- Structure and dynamics of the crystalline stable phase of 2-Chlorothiophene
Romanini, M.; Negrier, P.; Del Barrio, M.; Mondieig, D.; Serra, P.; Zuriaga, J.; Macovez, R.; Tamarit, J. Ll.
Crystal growth and design 19, 6405-6413 (2019)

20- Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release
Valenti, S.; Diaz, A.; Romanini, M.; del Valle, LJ.; Puiggali, J.; Tamarit, J. Ll.; Macovez, R.
International journal of pharmaceutics 568, 1-11 (2019)

21- Nose temperature and anticorrelation between recrystallization kinetics and molecular relaxation dynamics in amorphous morniflumate at high pressure
Romanini, M.; Valenti, S.; Del Barrio, M.; Tamarit, J. Ll.; Macovez, R.; Rodríguez, S.
Molecular pharmaceutics 16, 3514-3523 (2019)

22- Segmental relaxation and partial crystallization of chain-extended Poly(l-lactic acid) reinforced with carboxylated carbon nanotube
Yousefzade, O.; Valenti, S.; Puiggali, J.; Garmabi, H.; Macovez, R.
Journal of polymer science. Part B, polymer physics 57, 222-233 (2019)

23- Enhancement of the physical and chemical stability of amorphous drug-polymer mixtures via cryogenic comilling
Romanini, M.; Lorente, M.; Schammé, B.; Delbreilh, L.; Dupray, V.; Coquerel, G.; Tamarit, J. Ll.; Macovez, R.
Macromolecules 51, 9382-9392 (2018)

24- Tuning the Kinetic Stability of the Amorphous Phase of the Chloramphenicol Antibiotic
Valenti, S.; Romanini, M.; Franco, L.; Puiggali, J.; Tamarit, J. Ll.; Macovez, R.
Molecular pharmaceutics 15, 5615-5624 (2018)

25- Simultaneous orientational and conformational molecular dynamics in solid 1,1,2-Trichloroethane
Romanini, M.; Mitsari, E.; Tripathi, P.; Serra, P.; Zuriaga, J.; Tamarit, J. Ll.; Macovez, R.
Journal of physical chemistry C 122, 5774-5783 (2018)

26- Physical properties of organic fullerene cocrystals
Macovez, R.
Frontiers in Materials 4, (2018)

27- Relaxation dynamics vs crystallization kinetics in the amorphous state: the case of Stiripentol
Ruiz, G.; Romanini, M.; Del Barrio, M.; Tamarit, J. Ll.; Pardo, L.; Macovez, R.
Molecular pharmaceutics 14, 3636-3643 (2017)

28- Formulation and characterization of mucoadhesive controlled release matrix tablets of captopril
Saurí, J.; Zachariah, M.; Macovez, R.; Tamarit, J. Ll.; Zurita, D.; Suñé, M.; García, E.; Pérez, P.; Miñarro, M.; Ticó, J.; Suñé, J.
Journal of drug delivery science and technology 42, 215-226 (2017)

29- Thermodynamic scaling of the dynamics of a strongly hydrogen-bonded glass-former
Romanini, M.; Del Barrio, M.; Macovez, R.; Ruiz, M.; Capaccioli, S.; Tamarit, J. Ll.
Scientific reports 7, 1346 (2017)

30- Genuine antiplasticizing effect of water on a glass-former drug
Ruiz, G.; Romanini, M.; Hauptmann, A.; Loerting, T.; Shalaev, E.; Tamarit, J. Ll.; Pardo, L.; Macovez, R.
Scientific reports 7, 1-8 (2017)

31- Protonic surface conductivity and proton space-charge relaxation in hydrated fullerol
Mitsari, E.; Romanini, M.; Del Barrio, M.; Tamarit, J. Ll.; Macovez, R.
The journal of physical chemistry. Part C, nanomaterials and interfaces 121, 4873-4881 (2017)

32- Orientational relaxations in solid (1,1,2,2)tetrachloroethane
Tripathi, P.; Mitsari, E.; Romanini, M.; Serra, P.; Tamarit, J. Ll.; Zuriaga, J.; Macovez, R.
Journal of chemical physics 144, 164505 (2016)

33- Variable-range electron hopping, conductivity cross-over and space-charge relaxation in C60Br6
Zachariah, M.; Romanini, M.; Zygouri, P.; Gournis, D.; Tamarit, J. Ll.; Del Barrio, M.; Macovez, R.
Synthetic metals 217, 123-128 (2016)

34- C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
Mitsari, E.; Romanini, M.; Qureshi, N.; Tamarit, J. Ll.; Del Barrio, M.; Macovez, R.
The journal of physical chemistry. Part C, nanomaterials and interfaces 120, 12831-12839 (2016)

35- Double primary relaxation in a highly anisotropic orientational glass-former with low-dimensional disorder
Romanini, M.; Del Barrio, M.; Capaccioli, S.; Ruiz, M.; Macovez, R.; Tamarit, J. Ll.
The journal of physical chemistry. Part C, nanomaterials and interfaces 120, 10614-10621 (2016)

36- Solid state physicochemical properties and applications of organic and metallo-organic fullerene derivatives
Mitsari, E.; Romanini, M.; Zachariah, M.; Macovez, R.
Current organic chemistry 20, 645-661 (2016)

37- Structure and reorientational dynamics of 1-F-adamantane
Ben Hassine, B.; Negrier, P.; Romanini, M.; Del Barrio, M.; Macovez, R.; Kallel, A.; Mondieig, D.; Tamarit, J. Ll.
Physical chemistry chemical physics 18, 10924-10930 (2016)

38- Molecular diffusion and dc conductivity perfectly correlated with molecular rotational dynamics in a plastic crystalline electrolyte
Zachariah, M.; Romanini, M.; Tripathi, P.; Tamarit, J. Ll.; Macovez, R.
Physical chemistry chemical physics 17, 16053-16057 (2015)

39- Water-Triggered Conduction Mediated by Proton Exchange in a Hygroscopic Fulleride and Its Hydrate
Zachariah, M.; Mitsari, E.; Romanini, M.; Zygouri, P.; Gournis, D.; Del Barrio, M.; Tamarit, J. Ll.; Macovez, R.
The journal of physical chemistry. Part C, nanomaterials and interfaces 119, 685-694 (2015)

40- Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic
Tripathi, P.; Romanini, M.; Tamarit, J. Ll.; Macovez, R.
International journal of pharmaceutics 495, 420-427 (2015)

41- Self-diffusion, phase behavior, and Li+ ion conduction in succinonitrile-based plastic cocrystals
Zachariah, M.; Romanini, M.; Tripathi, P.; Del Barrio, M.; Tamarit, J. Ll.; Macovez, R.
The journal of physical chemistry. Part C, nanomaterials and interfaces 119, 27298-27306 (2015)

42- Silicon-Chip-Based Dielectric Spectroscopy for Conductivity and Molecular Dynamics Studies of Organic Films
Tripathi, P.; Gonzalo, J.; Mitsari, E.; Zachariah, M.; Romanini, M.; Tamarit, J. Ll.; Muñoz-Berbel, X.; Macovez, R.
Journal of Physical Chemistry Letters 5, 2796-2801 (2014)

43- Hopping conductivity and polarization effects in a fullerene derivative salt
Macovez, R.; Zachariah, M.; Romanini, M.; Zygouri, P.; Gournis, D.; Tamarit, J. Ll.
The journal of physical chemistry. Part C, nanomaterials and interfaces 118, 12170-12175 (2014)

44- Ultraslow dynamics of water in organic molecular solids
Macovez, R.; Mitsari, E.; Zachariah, M.; Romanini, M.; Zygouri, P.; Gournis, D.; Tamarit, J. Ll.
The journal of physical chemistry. Part C, nanomaterials and interfaces 118, 4941-4950 (2014)

45- Molecular conformation in organic films from quantum chemistry ab initio calculations and second harmonic spectroscopy
Macovez, R.; López Bigas, N.; Mariano, M.; Maymó, M.; Martorell, J.
The journal of physical chemistry. Part C, nanomaterials and interfaces 116, 26784-26790 (2012)

46- Large Optical-Frequency Shift of Molecular Radiation via Coherent Coupling to an Off-Resonance Plasmon
Macovez, R.; Mariano, M.; Finizio, S.; Kozyreff, G.; Martorell, J.
Physical review letters 107, 7 (2011)

47- Surface hubbard U of alkali fullerides
Macovez, R.
Journal of electron spectroscopy and related phenomena 183, 94-100 (2011)

48- Molecular X(2) gratings via electron-beam lithography
Domínguez, J.; Macovez, R.; Ujue, M.; Martorell, J.
Applied physics letters 97, 3 (2010)

49- New approaches for the fabrication of photonic structures of nonlinear optical materials
Carvajal, J.; Peña, A.; Kumar, R.; Pujol, M.; Mateos, X.; Aguiló, M.; Díaz, F.; Rodríguez, J.; Mendez, C.; Moreno, P.; Roso, L.; Trifonov, T.; Rodriguez, A.; Alcubilla, R.; Král, Z.; Ferré-Borrull, J; Pallarès, J.; Marsal Garvi, L. F.; Finizio, S.; Martorell, J.; Macovez, R.
Journal of luminescence 129, 1441-1447 (2009)

50- Measurement of the dispersion of air and of refractive index anomalies by wavelength- dependent nonlinear interferometry
Macovez, R.; Mariano, M.; Finizio, S.; Martorell, J.
Optics express 17, 13881-13888 (2009)